The nasopharyngeal cancer (NPC) is common human cancer patients in wouldwide. Human papilloma virus (HPV) infection have been shown association to NPC. This stuqy was performed to examine the dinical, sub-clinical sighs and HPV infection in patients with NPC. The results showed that the prevalence of NPC men were higher than femal (39/9). Histological analysis of', NPC tissue indicated type I 2,1 percent, type II 4,2 percent and type III 93,7 percent. HPVDNA was found 9/48 (18.75 percent) In NPC tissue samples. This study indicated that type III of NPC was frequent type and HPV infection was associated to NPC.