Thread is carried by the method of cross-sectional descriptive study analysis combir:Jed retrospective study on 193 patients addicted to drug substances are treated at the HIV/AIDS prevention center in Ninh Binh province. The results showed the following re1evant factors: - The group of patients with doses methadone remained less than 80 mg with high rates in the following subjects: groups not infected with HIV/AIDS (p0.01), the non-risk or low risk of depression (p0.01), group addicted to CDTP, ATS and tobacco (p0.05), group with dose from days 54 days or less: (p0.0001). - The group of patients infected with HIV/AIDS has a high rate in the following groups: group- QHTD with GBD, group QHTD with GBD with non-regular condom use, group using TCMT, sharing BKT, group paying for drugs/day from 412,000 VND or less, with p0.05. - The group of patients not infected with HCV has a higher rate of HBV infection 3.80 times than HCV group, with p0.0001. - The percentage of patients with employment and income increased over time of treatment, with p0.0001. - The group of patients with violations of laws and a high percentage of the target group: at the age of 24 and younger group, the group with depression levels at high risk. The difference was statistically significant, with p0.01.