Introduction: Nowaday, laparoscopy has developed strongly. The progress of laparoscopy such as mini-invasive, anesthesia, patients dischared early... Since the progress of this approach, the authors conduct technical studies on laparoscopic cholecystectomies with cardiovascular disease. Material and method: 60 patients laparoscopy at the Department of Anesthesiology- A, Hue Central Hospital in 2010, Age 63x24, Males/females: 41/1, 37 NYHA I, 16 NYHA 11, 7 NYHA 111. Stenosis mitral valve: 14, Insufficient mitral valve: 11, Stenoinsufficient mitral: 19, Insufficient aortic valve: 16 and Atrial fibrillation with 4. Results: Pulse (Preop 71 x18, Perop 77I16, Postop73x20, p0.05), Systolic Pressure (Preop 122x27, Perop 134x35, Postop 138x20, p0.05), Diastolic Pressure (Preop 70x12, Perop 75x21, Postop 78x14, p0.05), Sp02 100 percent. Conclusion: Laparocopic cholecystectomy can perform in cardiovascular diseases, but should evaluate carefully the parameters of anesthesia before and after operation. Protocole etomidate, fentanyl hight doses, muscle relaxant Vecuronium (Norcuron), maintained with Sevoflurance have vel}' good results.