Through evaluating the effectiveness of hypertonic saline 7.5 percent NaCl in 33 patients with severe traumatic brain injury (TBI), with Glasgow from 3-8 points, the brain resuscitation therapy routine: Sedation, ventilation, Reducing blood pressure to ensure... intracranial pressure in NaCl 7.5 percent when ICP 20 mm Hg in 5 minutes after exclusion of other causes: anti-breathing, fever, muscle contraction at a dose of 2 ml / kg / hour. the authors found that NaCl 7.5 percent who are not only effective in reducing ICP but also improves cerebral perfusion pressure. The changes of electrolytes, osmotic concentration did not affect the treatment process, not affect renal function.