Prawn-tilapia polyculture is economic efficiency model, which is able to reduce the degradation of the environment and effectively prevent disease. The model is the suitable solution for recovering tiger prawn in uncultivated prawn areas where were devastated by disease outbreak and environmental degradation. This model is able to successfully apply to local infrastntcture, investment, technical level and management level in some provinces, along the coast. Results indicated that after 4 months of polyculture tilapia was done in prawn ponds, the prawn and the fish grew well, they gained commercial size, while the pond environment is stable, the disease did not occur. Fish yield reached 3.57 tons/ha, farmed prawn production reached 0.78 tons/ha. Net profit reached 79.8 million VND/ha.