Hand hygiene (HH) before and after contacting with patients is considered as simplest and most costeffective solution which can reduce the risk of nosocomial infection by 50 percent. This study aims to describe HH situation among doctors and nurses at 7 clinical deparlments in Khanh Hoa general hospital, which can provide evidence for selecting feasible intervention solutions. This is cross-sectional study using mixed methods. Quantitative data on HH were collected by observing all 214 doctors and nurses. Qualitative data were collected by conducting 2 in-depth interviews (IDI) with hospital managers and 7 focus group discussions (FGD) in 7 deparlments to explaining for quantitative findings and proposing intervention solutions. The study reveals that the rates of practising HH and correctly fol/owing HH procedure are very low of 14.8 percent and 62.1 percent respectively. Pediatric deparlment has the highest rate of practising HH (39.7 percent) while there are two deparlments (Chest and Spine Oeparlments) having the lowest HH rates (0 percent). Information from 10ls and FGOs provides some reasons for this situation are inappropriate perception and knowledge of health staff on HH, iffelevant HH facilities and monitoring of the hospital. Three intervention solutions are identified including training for staff, strengthening supervision and monitoring and provide more HH facilities. Khanh Hoa hospital needs to conduct aIl these three solutions to improve HH situation.