Objective: Report of some brain lymphoma non-hodgkin patients were treated by cyberknife radiosurgery. Subject and method: In CyberKnife center of the No.108 Military Central Hospital, the authorsconducted CyberKnife radiosurgery for some patients with brain lymphoma. Radiation dose: 1900-2800cGy, Fractionated: 1-3Fx, Isodose line: 77-80 percent. Result: All patients are completely improvement of clinical and all tumors disappear in MRI after CK radiosurgery 3 months. Conclusion: CK radiosurgery is an effective method for local treatment and aids other whole body treatments with the brain lymphoma non-hodgkin. It has been feasibility, safety and high effectiveness.