Wilson disease is a copper metabolism disorder, inherited in an autosomal recessive, causes excessive copper accumulation in the liver, brain, kidney, cornea... Therapy for Wilson disease treatment: copper-chelating agents (Dpenicillamine or Trientin), Zinc combined low copper diet. Some Wilson patients developed nephrotic syndrome after a period of treatment with D-Penicillamine, the cause of nephrotic syndrome can be caused by side effects of the drug D- Penicillamine on the kidneys or by the accumulation of copper which injury kidney of wilson's disease. A number of reports about the Wilson patients who developed nephrotic syndrome after a period of treatment with D-Peni-cillamine were treated by stopping 0penicillamine and switched to Trientin or steroids. The authors report three patients with Wilson's disease who developed nephrotic syndrome after a period of treatment with D-Penicillamine treatment.