Among several approaches to teaching and learning a foreign language, Total Physical Response (TPR) is one that simulates the way children naturally acquire their mother tongue. Instructors give commands to students in the new language, and students respond through gestures. This article explores the principle and feature of TPR, and its advantages and disadvantages. This article also presents a study on the use of TPR in teaching English of the first -year non-English major students at Thainguyen University of Information and Communication Technology (lCTU) and provides some suggestions for applying TPR.