The effects of using different feed sources on the growth and survival of the Ben Tre clam were carried out in the earthen ponds of 500m2 at a stocking density of 150 clam/m2. The experiment consisted of three food source treatments: natural foods in seawater through water exchange (CT1), food from algae biom"lss production in clam ponds(CT2), and a combination of natural foods through water exchange and food from algae biomass ponds (CT3). Results showed that NH4 and chlorophyll-a concentrations in the treatment CT2 were 0.54 +/- 0.04 mg/L and 6.80 +/- 0.02 ug/L, respectively, and was significantly (P0,05) higher than those in CT1 and CT2 treatments. Growth and survival rates of the clam were highest in CT3 (0.60 percent/day and 86.99 percent, respectively) and were significantly higher than those in the treatment CT2 (0.37 percent/day and 75.45 percent). There were no significant difference between CT1 and CT2 in growth and survival rates (P0.05). Research results recommended that combination of natural food source in seawater through water exchange and food from algae biomass pond are suitable for commercial farming of clams in pond.