Objective: To investigate the clinical features of erythema multiform at the National Hospital of Dermatology and Venereology (NHDV). Subject and methods: A prospective study based pn 41 patients with erythema multiform at NHDV. Result: 41 patients with erythema multiform were involved, in which 51.22 percent were male and 48.78 percent were female. The average age was 34.80 +/- 20.97. Clinical manifestations were fever (34.14 percent), itching (92.68 percent), predome (24.39 percent), erythema and target lesion (92.68 percent), oedema papules (87.80 percent) and bulla (26.83 percent). The eryptions were mainly located on the extrimities such as hands (70.59 - 97 percent), feet (37 percent) and faces (41.46 percent). Oral mucosal lesions accounted for 39.03 percent and those on the genital area -19.52 percent. The major type was 39.02 percent and minor type was 60.98 percent of the patients. Conclusion: Erythema multiform was present in both sexes. The main clinical features were erythema and target eruptions, located frequently on the extremities. The mucosal eruptions mainly were in the mouth and genital area. Itching was very common and most of the patients suffered the mild form.