The formation of nanoscale dropletslbubbles from a metastable bulk phase is still connected to many unresolved scientific questions. In this work the authors analyze the stability of multicomponent liquid droplets and bubbles in closed Nj, V, T systems (total mass of components, total volume and temperature). To investigate this problem, square gradient theory combined with an accurate equation of state is used. the authors compare the results from the square gradient model to the macroscopic capillary description. the authors find that both predict a finite threshold size for dropletslbubbles. The work reveals a metastable region close to the minimal dropletlbubble radius. The authors find that the liquid compressibility is crucial for the existence of this minimum threshold size for bubble formation.