The first organ transplantation (Tx) in Vietnam such as kidney Tx in June 1992, liver Tx in January 2004 and heart Tx in June 2010) were successfully performed at No.103 Hospital, Military Medical University. Until August 2013, nearly 850 cases of kidney Tx were perforriled in 12 Vietnamese hospitals, including 48 cadaveric kidney Tx and more than 160 living donor nephrectomy by endoscopy. Thirty three cases of liver Tx, including 20 living donor liver Tx (LDLT) and 13 cases from brain death patients, were carried out in 5 centers of the country. Nine cases of heart Tx were performed from brain death donor in 3 hospitals. In recent years, the organ Tx in Vietnam has been remarkably improved and innovated with promising results for new domestic treatment of end-stage organ failure, which pushed up development of medicine field in the country and helped us upgrade the level of organ Tx in the world. The success of organ Tx has contributed intensification of unity and cooperation among scientists in general as well as domestic and international medical centers in particular and brought a lot of economic and social benefits.