A series of new chalcone derivatives was synthesized based on 2,4-dihydroxyacetophenone through a two-step procedure. The first step was the reaction of 2,4-dihydroxyacetophenone (1) with propargyl bromide in acetone under reflux condition for 72 hours using K2CO3 as a catalyst to give the intermediate 2. The second step was the Claisen Schmidt condensation of 2 with different aldehydes in methanol in the presence of NaOH as a catalyst at room temperature to obtain new chalcons 3a-g in 68-82 percent yields. The structure of synthesized compounds was elucidated using IR, NMR and MS spectra.