Tổng hợp các Chalcon mới trên cơ sở 2,4-Dihydroxyacetophenone

• Tác giả: Lê Anh Nguyễn, Văn Minh Nguyễn, Khắc Vũ Trần, Tuấn Kiên Vũ
• Ngôn ngữ: vie
• Ký hiệu phân loại: 545.9 Quantitative analysis
• Thông tin xuất bản: Khoa học và Công nghệ các trường đại học kỹ thuật, 2014
• Mô tả vật lý: 134-137
• Bộ sưu tập: Metadata
• ID: 506640

Tóm tắt

A series of new chalcone derivatives was synthesized based on 2,4-dihydroxyacetophenone through a two-step procedure. The first step was the reaction of 2,4-dihydroxyacetophenone (1) with propargyl bromide in acetone under reflux condition for 72 hours using K2CO3 as a catalyst to give the intermediate 2. The second step was the Claisen Schmidt condensation of 2 with different aldehydes in methanol in the presence of NaOH as a catalyst at room temperature to obtain new chalcons 3a-g in 68-82 percent yields. The structure of synthesized compounds was elucidated using IR, NMR and MS spectra.