BACKGROUND: The FACE-Q Aesthetics is a validated tool for assessing patient-reported outcomes related to surgical and non-surgical facial aesthetic treatments. Recognizing patient-specific variables that may influence FACE-Q scores is essential to control for potential confounders in research. OBJECTIVES: This study aimed to identify factors that predict FACE-Q Aesthetic scale scores. METHODS: A cross-sectional survey was conducted among an international cohort of participants recruited through the Prolific platform. Participants aged 20 years or older who had undergone non-invasive facial aesthetic procedures within the past year were included. Demographic and clinical information was collected, and univariable and multivariable linear regression analyses were employed to assess predictors of FACE-Q Face Overall, Psychological, and Social scale scores. RESULTS: A total of 1,259 participants were analyzed, with an average age of 42.6 years (±11.9). The mean scores were 52.4 (±18.3) for the Face Overall scale, 56.5 (±23.7) for the Psychological scale, and 62.7 (±24.0) for the Social scale. Several factors were significantly associated (p <
0.05) with higher scores, including lower body mass index (BMI), African American ethnicity, male gender, Fitzpatrick skin type V, residence in the United States, financial stability, and residual effects of prior aesthetic treatments. Younger participants were more likely to report higher Face Overall scores (p<
0.05). CONCLUSIONS: This study identified several patient characteristics that predict Face Overall, Psychological, and Social scale scores. These findings offer valuable insights into how patient-specific factors influence outcomes following facial aesthetic procedures and underscore the need to account for these variables in future research using the FACE-Q Aesthetics tool.