Nonislet Cell Tumor Hypoglycemia: A Rare Paraneoplastic Syndrome.

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Tác giả: Aishwarya Gaur, Prabhat Narain Sharma, Shyam Sunder

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: India : The Journal of the Association of Physicians of India , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 5123

Nonislet cell tumor hypoglycemia (NICTH) is a rare and underreported cause of hypoglycemia due to excessive production of insulin-like growth factor 2 (IGF-2) and its intermediate forms, which activate the insulin receptor. Typically, certain malignancies can cause NICTH, usually as a paraneoplastic syndrome. Diagnosis requires a raised IGF-2/IGF-1 ratio. Surgery forms the cornerstone of management, while glucocorticoids are an alternative when surgery is not possible. We present a unique case of a 27-year-old male, who was a follow-up case of chronic hepatitis B infection and presented with a gall bladder fossa mass and recurrent, severe episodes of hypoglycemia. Workup revealed low insulin and C-peptide and suppressed IGF-1 with normal pituitary function. Clinicians should consider the possible diagnosis of NICTH when laboratory and immunohistochemical (IHC) data do not support more common causes, such as insulinoma.
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