Natural compound PEITC inhibits gain of function of p53 mutants in cancer cells by switching YAP-binding partners between p53 and p73.

• Tác giả: Jing-Cai Cheng, Ying Huang, Guo-Yu Li, Yan Shen, Li-Wei Wang, Yi-Xuan Wang, Xue-Feng Wu, Qiang Xu, Jia-Wen Yang, Lin Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 338.54 Economic fluctuations
• Thông tin xuất bản: United States : Acta pharmacologica Sinica , 2025
• Bộ sưu tập: NCBI
• ID: 51236

Tóm tắt

Phenethyl isothiocyanate (PEITC) derived from cruciferous vegetables has shown anticancer activities by modulating apoptosis, cell cycle arrest, drug-metabolizing enzymes and even preferentially restoring a 'WT-like' conformation to p53