A woman in her thirties and in her second trimester of pregnancy presented with fever, shaking chills, and shortness of breath of 5-6 days duration. She developed progressive hypoxemia and tachypnea, leading to the development of acute respiratory distress syndrome (ARDS). An aerobic blood culture showed positivity for Salmonella typhi. Her worsening respiratory distress was treated with oxygenation through a high-flow nasal cannula. She was stabilized with intravenous (IV) antibiotics and other supportive measures and was discharged home with a live fetus in utero.