INTRODUCTION: The increasing stress of modern life has led to a decline in immunity, sparking widespread interest in new strategies to boost immune function. METHODS: Mice were divided into the normal control group, model control group (normal saline), positive drug control group (levamisole hydrochloride, 10 mg/kg), and low, medium, and high-dose groups (1.5×10 RESULTS: The combination significantly improved immune organ atrophy, restored intestinal morphology, and normalized cytokine levels in immunosuppressed mice, indicating enhanced immune function. Additionally, it restored intestinal microbiota diversity by increasing the abundance of DISCUSSION: The combination of