BACKGROUND: Childhood cancer has become a pressing global concern, impacting over 200,000 children annually, and is projected to escalate to 21 million diagnoses by 2030. This article discusses the growing incidence of pediatric cancer in India, describes the unique obstacles it faces, and encompasses a strategy for solving this pressing problem. METHODS: We reviewed published scientific literature and available information on cancer control and prevention programs in India. RESULTS: According to the National Cancer Registry Programme, in India, childhood cancers (0-14 years) constitute 4.0% of all cancer cases. The surge in childhood cancer cases in India mirrors a global trend, emphasizing the necessity for a comprehensive understanding of contributing factors. Pediatric oncology in India faces challenges arising from limited rural healthcare access, resulting in delayed diagnosis and treatment. Socioeconomic factors hinder specialized pediatric cancer care, accentuating the need to bridge these gaps through targeted interventions, improved infrastructure, and policies. Additionally, there are limited population-level epidemiologic studies on environmental, lifestyle, and genetic risk factors and childhood cancers. Research on genetic and environmental determinants is crucial for developing effective treatments. Addressing this requires public education, enhanced medical and research training, community-based cancer screening, and integrated medical care initiatives. Advocacy and awareness campaigns play a vital role in tackling pediatric cancer challenges, supported by grassroots initiatives and collaboration between the government and nongovernmental organizations. CONCLUSION: Despite recent efforts by the Ministry of Health, Government of India, childhood cancer lacks a specific policy in India. Urgent collective efforts are needed to address challenges, invest in research, enhance awareness, and advocate for policy changes. It is time for healthcare professionals, policymakers, researchers, and the public to collaborate and ensure no child in India is left behind in the fight against pediatric cancer, paving the way for a healthier future for the nation's youngest members.