Sustained Fisetin Release Prevents Orthodontic Ti-6Al-4V Screw Failure by Suppressing Peri-Implantitis and Alveolar Bone Resorption.

• Tác giả: Yoshiya Hashimoto, Yoshitomo Honda, Jun-Ichiro Jo, Runbo Li, Naoyuki Matsumoto, Aki Nishiura, Susumu Tsuda, Ruonan Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : ACS biomaterials science & engineering , 2025
• Bộ sưu tập: NCBI
• ID: 5162

Tóm tắt

In clinical practice, mini-screws of titanium-6-aluminum-4-vanadium alloy with an extra low interstitial (ELI) grade (Ti-6Al-4V ELI) are widely used as orthodontic anchorages. However, in orthodontic treatment, Ti-6Al-4V mini-screw failure because of peri-implantitis is a major challenge. To prevent damage caused by peri-implantitis, we developed a novel Ti-6Al-4V disc/screw coated with poly(lactide-