Heterobifunctional cross-linker with dinitroimidazole and azide modules for protein and oligonucleotide functionalization.

• Tác giả: Yaoguang Hua, Juncheng Li, Shuli Liu, Chunqiu Long, Qunfeng Luo, Sijia Lv, Yuzhi Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 952.03 1868-1945
• Thông tin xuất bản: England : RSC advances , 2025
• Bộ sưu tập: NCBI
• ID: 51714

Tóm tắt

Dinitroimidazole (DNIm) was recently identified as a powerful bioconjugation agent that could selectively modify thiol over amine on biomolecules at an ultrahigh speed in an aqueous buffer. However, its derivative containing a DNIm module and a terminal alkyne module failed to construct functional agents bearing a DNIm warhead