WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: The number of reported cases of human brucellosis significantly increased from 45,046 (3.25/100,000) in 2019 to 70,439 (4.99/100,000) in 2023. WHAT IS ADDED BY THIS REPORT?: Human brucellosis continued to spread and expand of in northern China, with the most cases reported in the Inner Mongolia Autonomous Region ( WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: With the continued worsening of human brucellosis over the past five years, implementing strict controls on the movement of infected animals is urgeent.