Anesthesia management for a pregnant patient with Guillain-Barré syndrome (GBS) requires careful planning to ensure the safety of both the mother and fetus while addressing its specific physiological challenges. Management should involve a coordinated team of anesthesiologists, obstetricians, neurologists, and intensivists to optimize outcomes for the mother and fetus. There appear to be no specific case reports that directly document the use of supraglottic airway devices (SGADs) in managing patients with GBS. GBS is a rare, acute autoimmune disorder in which the body's immune system attacks the peripheral nervous system, leading to muscle weakness and potentially life-threatening complications like respiratory failure. GBS during pregnancy is particularly challenging due to its rarity and the need to balance maternal and fetal health. GBS is often preceded by infections (e.g., Campylobacter jejuni, cytomegalovirus) or other immune system triggers. Here, we describe the successful anesthetic management with SGAD of a 28-year-old pregnant woman with GBS following a gastrointestinal infection.