RA-PR058, a novel ramalin derivative, reduces BACE1 expression and phosphorylation of tau in Alzheimer's disease mouse models.

• Tác giả: Hongchan An, Yujung Byun, Minshik Chae, Heewon Cho, Yongeun Cho, Sukmin Han, Ju-Mi Hong, Jun-Goo Jee, Yeji Jeon, Dong-Gyu Jo, Seongeun Kang, Hyunwook Kim, Jun-Sik Kim, Soyeong Kim, Sung Hyun Kim, Tai Kyoung Kim, Jeongmi Lee, Yeongyeong Lee, Yujeong Lee, Leon F Palomera, Sang Yoon Park, Sunyoung Park, Joung Han Yim
• Ngôn ngữ: eng
• Ký hiệu phân loại: 271.6 *Passionists and Redemptorists
• Thông tin xuất bản: England : Animal cells and systems , 2025
• Bộ sưu tập: NCBI
• ID: 51972

Tóm tắt

 Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by cognitive decline, anxiety-like behavior, β-amyloid (Aβ) accumulation, and tau hyperphosphorylation. BACE1, the enzyme critical for Aβ production, has been a major therapeutic target
  however, direct BACE1 inhibition has been associated with adverse side effects. This study investigates the therapeutic potential of RA-PR058, a novel ramalin derivative, as a multi-targeted modulator of AD-related pathologies. The effects of RA-PR058 were evaluated