A Consecutive Two-Step Radical-Mediated Cyclization of gem-Difluorinated Diynes to Access gem-Difluorinated Cedrene.

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Tác giả: Chutima Kuhakarn, Darunee Soorukram, Watcharaporn Thaharn

Ngôn ngữ: eng

Ký hiệu phân loại: 721.83 Means of vertical access

Thông tin xuất bản: Germany : Chemistry, an Asian journal , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 52032

A consecutive two-step radical-mediated cyclization of gem-difluoromethylenated bis(3-arylpropagyl)-indane-1,3-diones to access structurally unique gem-difluoromethylenated cedrenes is described. Substituents located on the aryl rings of the two propagyl units play an important role in governing the consecutive cyclization pattern. Upon treatment of gem-difluoromethylenated 1,3-diane with Bu3SnH/AIBN, a tributylstannyl radical-mediated radical cyclization between the two diyne units chemoselectively took place, leading to the corresponding gem-difluoromethylenated acoradienes in good yields, after removal of tributylstannyl group by TFA.  Subsequently, Bu3SnH/AIBN promoted reductive cleavage of the phenylsulfanyl group leading to difluoroalkyl radicals which spontaneously underwent radical cyclization to give a series of gem-difluoromethylenated cedrenes.
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