Therapeutic potential of nicotinamide and ABT263 in alcohol-associated liver disease through targeting cellular senescence.

• Tác giả: Wenjing Cao, Qinchao Ding, Xinxuan Ge, Naheemat Modupeola Gold, Yonghan He, Songtao Li, Qiuni Luo, Ayesha Nisar, Michael Ngozi Okeke, Yongzhang Pan, Shaoyan Pu, Rui Tian, Xiayan Wang, Han Xu, Pengyun Yang, Yang Yang, Xingjie Zhang, Meiting Zi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 636.0885 Animal husbandry
• Thông tin xuất bản: China : MedComm , 2025
• Bộ sưu tập: NCBI
• ID: 52042

Tóm tắt

Alcohol-associated liver disease (ALD) is a major cause of liver-related morbidity and mortality, yet clinically effective therapies for ALD remain lacking. Here, we demonstrate that alcohol intake and its metabolite, acetaldehyde (ACH), induce senescence in the liver and liver cells, respectively. To assess the therapeutic potential of targeting liver senescence in ALD, we treated ALD-affected mice with the senolytic compound ABT263 and the senomorphic NAD