BACKGROUND: Snail slime (SS), a complex biological substance produced by various snail species, has garnered significant attention in recent years due to its diverse applications in health, cosmetics, and biotechnology. AIMS: Our previous review focused on the biological activities of SS, while the current one explores the science behind SS with a special focus on environmental factors affecting its quality and quantity, non-lethal extraction methods, its composition, current applications in health and cosmetics followed by its emerging applications, and future prospects while achieving sustainability. METHODS: A literature review on background, uses in health and cosmetics, and future prospects of SS was conducted. PubMed and Google Scholar were used to find the key articles exploring SS and the data is summarized and described here. RESULTS: Extraction methods range from traditional farming practices to advanced, non-invasive techniques aimed at minimizing stress on snails. Emerging applications include potential use in sustained and targeted drug delivery systems, tissue engineering, and as components in advanced biomaterials. Future perspectives involve technological advancements in production, such as precision farming and biotechnology-enhanced mucin production. The development of synthetic alternatives and sustainable practices is crucial for the industry's long-term viability. CONCLUSION: As research continues to uncover new properties and applications, SS is poised to play an increasingly important role in the health and beauty industries, highlighting the need for balanced exploitation, standardization, quality control, and regulatory compliance in its production and use.