BACKGROUND: Work engagement, a multifaceted concept encompassing dedication, vigour and absorption, is critical for paediatric intensive care unit (PICU) nurses who are providing critical care to ensure optimal patient care and maintain their well-being. AIM: This study examines the effect of a brief mindfulness-based intervention (MBI) on different dimensions of work engagement among PICU nurses. STUDY DESIGN: Using a quasi-experimental design with pretests and posttests across two groups, we evaluated the impact of a brief MBI on work engagement. Two hospitals were randomly selected to implement the intervention, and the other two served as controls. RESULTS: A total of 204 nurses participated, with 101 in the intervention group and 103 in the control group. Post-intervention, the intervention group exhibited significantly higher levels of vigour (M = 3.88, SD = 0.56), dedication (M = 4.67, SD = 0.64) and absorption (M = 4.18, SD = 0.56) compared with the control group (p <
.001 with 95% CI of -2.02, -1.62 for vigour
-2.23, -1.78 for dedication
and -1.89, -1.50 for absorption). The multivariate analysis of variance results indicated a significant effect of the intervention on the linear combination of dependent variables (V = .30, F[3, 200] = 29.22, p <
.001), with a substantial effect size (partial η CONCLUSION: The current study highlights the efficacy of a brief MBI in enhancing work engagement among paediatric ICU nurses. Thus, MBIs could be a practical solution to issues encountered in a demanding work environment. RELEVANCE TO CLINICAL PRACTICE: The brief MBI significantly enhanced the work engagement dimensions of vigour, dedication and absorption among PICU nurses. These improvements suggest that mindfulness practices effectively boost nurses' energy levels, sense of purpose and deep concentration, which are essential for high-quality patient care. The findings highlight the potential of integrating mindfulness interventions into health care settings to promote caregiver well-being and better patient outcomes.