Pulmonary sarcomatoid carcinoma（PSC）is a rare pathological type of non-small cell lung cancer that combines the characteristics of epithelial and mesenchymal tu-mors and is an extremely malignant and highly heterogeneous malignant tumor. PSC is dif-ficult to diagnose and has a poor sensitivity to radiotherapy. In recent years, with the effica-cy breakthroughs of molecularly targeted drugs and immune checkpoint inhibitors in tumor therapy, the treatment of PSC is gradually exploring precise targeted therapy and immuno-therapy. In this article, we will provide a comprehensive review of the clinical features, di-agnostic points, and progress in the clinical therapeutic research of PSC. We hope to provide guidance and help with clinical treatment and scientific research.