Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2.

• Tác giả: Wellington V Cardoso, Ziyuan Jiang, Neoklis Makrides, Hilal Mir, Carlos Serra, Neel H Shah, Emily Sun, Yihua Wu, Xin Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 598.442 *Gaviiformes (Loons)
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 521714

Tóm tắt

SHP2, a protein tyrosine phosphatase (PTP) crucial in Ras-MAPK signaling, is associated with various human congenital diseases and cancers. Here, we show that the catalytically inactive