Antibody Response to Covishield and Covaxin in Kidney Transplant Recipients.

• Tác giả: Shyam Bihari Bansal, Manish Jain, Amit Kumar Mahapatra, Neha Manhas, Abhyudaysingh Rana, Sidharth Kumar Sethi, Dinesh Kumar Yadav
• Ngôn ngữ: eng
• Ký hiệu phân loại: 155.935 Catastrophic disasters
• Thông tin xuất bản: India : Indian journal of nephrology , 2025
• Bộ sưu tập: NCBI
• ID: 52178

Tóm tắt

BACKGROUND: The COVID-19 pandemic had a major impact on solid organ transplant recipients. COVID-19 vaccination plays a crucial role in pandemic management.There is limited data on replication-defective viral vectors [ChAdOx1-nCOV (COVISHIELD MATERIALS AND METHODS: Anti-SARS-CoV-2 anti-spike antibody titers were measured in 285 KTRs recipients prior to vaccination, 3 weeks ± 3 days after first dose and 3 weeks ± 3 days after second dose of the COVISHIELD (n = 232) and COVAXIN (n = 55) vaccines. Anti-spike antibodies were measured by the chemiluminescence immunoassay method. The primary outcome was seroconversion after two doses of COVAXIN and COVISHIELD and secondary outcome was the incidence of adverse events to COVID-19 vaccines within one week of vaccination. RESULTS: At baseline, 25 (39.7%) and 67 (30.2%) of KTRs were found to be seropositive before receiving COVAXIN CONCLUSION: Both ChAdOx1-nCOV and BBV-152 were well tolerated and induced robust antibody formation in KTRs in the Indian population.