Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus.

• Tác giả: Stephen E Alves, Karen H Costenbader, Keishi Fujio, Yidan Gao, Alice Horisberger, Pui Y Lee, Marc C Levesque, Kathryne E Marks, Yujie Qu, Deepak A Rao, Takanori Sasaki, John Sowerby, Marc A Sze, Runci Wang, Yinan Xiao
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 522393

Tóm tắt

Pathologic T cell-B cell interactions drive disease in systemic lupus erythematosus (SLE). The T cells that activate B cell responses include T peripheral helper (Tph) and T follicular helper (Tfh) cells, yet the developmental and clonal relationships between these B cell-helper T cell populations are unclear. Here we use T cell receptor (TCR) profiling to demonstrate clonal overlap between Tph and Tfh cells in the circulation of patients with SLE. Expanded Tph and Tfh cell clones persist over the course of 1 year in patients with a new diagnosis of SLE, and clones are observed to shift both from Tfh to Tph cells and from Tph to Tfh cells over time. High resolution analysis of cells sorted as Tph cells (CXCR5