Receptor Allostery Promotes Context-Dependent Sonic Hedgehog Signaling During Embryonic Development.

• Tác giả: Shariq S Ansari, James P Bridges, Robin Canac, Taosheng Chen, Christina A Daly, Miriam E Dillard, Mohamed Ghonim, Ivan P Moskowitz, Stacey K Ogden, Shondra M Pruett-Miller, Jeffrey Steinberg, Daniel P Stewart, Paul G Thomas, Yong-Dong Wang, William C Wright, Yan Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 598.634 *Tetrao
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 522956
• Chủ đề: 1. Receptor; 2. Allostery; 3. Promotes

Tóm tắt

Sonic Hedgehog (SHH) signaling functions in temporal- and context-dependent manners to pattern diverse tissues during embryogenesis. The signal transducer Smoothened (SMO) is activated by sterols, oxysterols, and arachidonic acid (AA) through binding pockets in its extracellular cysteine-rich domain (CRD) and 7-transmembrane (7TM) bundle.