A Comparative Dosimetric Study of Proton and Photon Therapy in Stereotactic Arrhythmia Radioablation for Ventricular Tachycardia.

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Tác giả: Chih-Wei Chang, Kristin A Higgins, Pretesh Patel, Justin Roper, Keyur D Shah, Yuan Shao, Sibo Tian, Zhen Tian, Yinan Wang, Xiaofeng Yang, Jun Zhou

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : ArXiv , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 523444

 PURPOSE: Ventricular tachycardia (VT) is a life-threatening arrhythmia commonly treated with catheter ablation
  however, some cases remain refractory to conventional treatment. Stereotactic arrhythmia radioablation (STAR) has emerged as a non-invasive option for such patients. While photon-based STAR has shown efficacy, proton therapy offers potential advantages due to its superior dose conformity and sparing of critical organs at risk (OARs), including the heart itself. This study aims to investigate and compare the dosimetry between proton and photon therapy for VT, focusing on target coverage and OAR sparing. METHODS: We performed a retrospective study on a cohort of 34 VT patients who received photon STAR. Proton STAR plans were generated using robust optimization in RayStation to deliver the same prescription dose of 25 Gy in a single fraction while minimizing dose to OARs. Dosimetric metrics, including D RESULTS: Proton and photon plans achieved comparable target coverage, with VAS D CONCLUSION: Proton therapy for STAR demonstrates significant dosimetric advantages in sparing the heart and other critical OARs compared to photon therapy for VT, while maintaining equivalent target coverage. These findings highlight the potential of proton therapy to reduce treatment-related toxicity and improve outcomes for VT patients.
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