Kích thích buồng trứng và có thai lâm sàng của clomiphene citrate đơn thuần và clomiphen citrate kết hợp với FSH trong thụ tinh nhân tạo

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Tác giả: Thị Liên Hương Nguyễn, Xuân Hợi Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại: 571.864 +Fertilization

Thông tin xuất bản: Nghiên cứu Y học, 2017

Mô tả vật lý: 103-111

Bộ sưu tập: Metadata

ID: 535714

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Khảo sát kết quả kích thích buồng trứng và có thai lâm sàng của clomiphene citrate đơn thuần và clomiphene citrate kết hợp với FSH trên 100 chu kỳ thụ tinh nhân tạo được chia ngẫu nhiên thành 2 nhóm. Nhóm 1 gồm 50 chu kỳ kích thích buồng trứng bằng clomiphen citrate đơn thuần và nhóm 2 gồm 50 chu kỳ kích thích buồng trứng bằng clomiphene citrate kết hợp FSH. Kết quả cho thấy nhóm 1 có số nang noãn kích thước trên 18mm (1,5 ± 0,7), thấp hơn nhóm 2 (2,0 ± 1,2). Độ dày niêm mạc tử cung nhóm 1 là 8,3 ± 1,6 mm, thấp hơn nhóm 2 (10,0 ± 2,1 mm). Tỷ lệ quá kích buồng trứng nhẹ ở nhóm 1 là 6% và nhóm 2 là 14%. Tỷ lệ thai lâm sàng nhóm 1 là 20%, nhóm 2 là 22%. Phác đồ kích thích buồng trứng bằng clomiphene citrate kết hợp FSH cho kết quả cao hơn so với phác đồ dùng clomiphene citrate đơn thuần về số nang noãn trưởng thành trung bình, độ dày niêm mạc trung bình.The paper investigated the results of ovarian and clinical pregnancy stimulation of clomiphene citrate alone and clomiphene citrate in combination with FSH over 100 cycles of artificial insemination were randomly divided into 2 groups. Group 1 includes 50 cycles of ovarian stimulation with pure clomiphen citrate and group 2 consisting of 50 ovarian stimulation cycles with clomiphene citrate combined with FSH. The results showed that group 1 had the number of ovule follicles of over 18mm (1.5 ± 0.7), lower than group 2 (2.0 ± 1,2). The uterine lining thickness of group 1 was 8.3 ± 1.6 mm, lower than group 2 (10.0 ± 2.1 mm). The rate of ovarian hyperstimulation in group 1 is 6% and group 2 is 14%. Group 1 pregnancy rate is 20%, group 2 is 22%. Clomiphene citrate ovarian stimulation regimen combined with FSH resulted in higher results than the clomiphene citrate regimen alone in terms of the average number of mature oocytes, average mucosal thickness.

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