Obiectives: Osteocalcin is produced bv osteoblast cells, which are the onlv seeretorv cells that regulate the body's mineral metabolism, which niavs a role in the mineralization of bone. Osteocalcin acts as a homione in the body, which stimulates pancreatic beta cells to release insulin, and stimulates adiponectin-releasing hormone-releasing fatty cells that are insulin-sensitizing. In addition, recent studies have shown that osteocalcin enhances insulin sensitivity and the differentiation in muscle, while secreted factors from muscle, myokines. regulate bone metabolism. These findinas suqqest that bone metabolism and glucose metabolism are associated with each other through the action of osteocalcin. In this review, the authors investigated the association between osteocalcin levels and characteristics of patients with type 2 diabetes, such as fasdng glucose, HbA1c, insulin and HOMA2-IR. Methods: A cross - sectional study of 151 patients with type 2 diabetes and 67 healthy, non-diabetic patients was examined and treated at the Nghe An General Hospital from 7/2015 to 12/2017. Osteocalcin levels were measured in Diagnostic Automation, Inc., Human Osteocalcin ELISA kit from MELSIN by ELISA. Calculates the HOMA2-IR and HOMA2-% Beta ratios according to the HOMA Calculator v2.2.3 software version of Oxford University - UK. Data processing using SPSS 16.0 software. Results: Ostecalcin levels in type 2 diabetes (1.88 ± 1.21 ng/l) were statistically significantly (p<
0.01) lower than those without disease (2.52 ± 0.93 ng/l). Multiple regression analysis showed that serum osteocalcin levels were an inversely correlated with HbA1c (p = -0.243
p = 0.02) and H0MA2-IR (p = - 0.243
p = 0.015) in type 2 diabetes mellitus. There is a positive correlation between osteocalcin levels and pancreatic beta cell function (IH0MA2-% P). Conclusions: Osteocalcin levels are inversely related to HbA1c and HOMA2-IR in patients with type 2 diabetes mellitus.Xác định mối liên quan giữa Osteocalcin huyết thanh và chuyển hóa Glucose ở 151 bệnh nhân đái tháo đường type 2. Kết quả cho thấy nồng độ Ostecalcin huyết thanh có tương quan nghịch với HbA1c và Horma2-IR ở bệnh nhân tiểu đường type 2. Có sự tương quan thuận giữa nồng độ Ostecalcin và chức năng tế bào beta tụy.