Introduction: (Mutation of GSTP1 and NAT2 gene could reduce xenobiotics metabolism, which increases oxidation and causes chronic diseases including infertility. Oxidative stress is a common pathology seen in approximately half of all infertile men. This study aimed to describe some of the mutations of the NAT2 and GSTP1 genes and the association between this mutations and the oxidative stress level in primary male infertility. Material and Methods: A total 200 DNA samples (100 infertile patients and 100 fertile men) were genotyped for the polymorphisms by ARMS - PCR. Randomly selected 70 samples of seminal plasma (35 samples of infertile men and 35 samples of normal men) from 200 subjects were studied to determine the level of oxidative stress with Oxysperm kit (Haloteeh, Spam). Results: There was a significant association between the NAT2 variant genotypes (CT + TT (NAT2 (481C>
T)), (OR, 95% CI: 3,12, 95% (CI): 1,72-5,68, p <
0,001)) and GA + AA (NAT2 (590 G>
A)), (OR, 95% CI: 2,34, 95% (Q): 1,27-4,31, p <
0,001) and or NAT2 vanant genotypes (GA+AA) (GSTP1 (313G>
A), (OR, 95% CI: 5,25, 95% (Q): 2,71-10,19, p<
0,001))and CT + TT (GSTP1 (C341T)), (OR, 95% CI: 12,36, 95% (CI): 4,19 - 36,49, p<
0,001)) with idiopathic infertility risk. The findings also rate the significance of the effect of GSTP1 and/or NAT2 in modulating the risk of male infertility in males from Vietnam. The level of oxidative stress is high in patients carrying these mutations. Conclusions: This pilot study found, as far as is known for the firS time, that the polymorphisms GSTP1 (313G>
A) and (341C >
T)
NAT2 (481C >
T) and {590 G>
A)) were some novel genetic markers for susceptibility to, idiopathic male infertility, but the nsk is potentiated by exposure to various environmental oxidants.Xác định mối liên quan giữa các đột biến gen NAT2 và GSTP1 với vô sinh nam nguyên phát và stress oxy hóa trên 200 đối tượng, trong đó có 100 người bình thường và 100 nam giới vô sinh nguyên phát. Kết quả nghiên cứu cho thấy các đa hình gen GSTP1 (313>
A) và (341C>
T)
gen NAT2 (481>
C) và (590G>
A) có liên quan với vô sinh nam nguyên phát và tăng mức độ stress oxy hóa.