Nghiên cứu bào chế hệ phân tán rắn chứa aceclofenac đê tăng tác dụng chống viêm, giảm đau

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Tác giả: Thị Hồng Vân Nguyễn, Văn Bạch Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại: 615.783 Analgesics

Thông tin xuất bản: Y học Việt Nam, 2018

Mô tả vật lý: 14-18

Bộ sưu tập: Metadata

ID: 536181

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Objectives: Develop and evaluate some physicochemical properties of Acedofenac solid dispersions. Methods: Acedofenac solid dispersions were prepared by 2 methods: melting and solvent evaporation. The effects of the excipients as carriers: PEG 4000, PEG 6000 and PVP K30 on the charactenstics of the solid dispersion system were evaluated. Results: Evaluation by dissolution test showed the obtained improved the solubility and dissoluhon rate of ACE, and the formula with ACBPVP K30 (1:7) prepared by solvent evaporation method showed the best solubility and dissolution rate, exceeding 9.89 times and 4.53 times at 120 minutes, respectively. X-ray, DSC and SEM showed that Acedofenac existed mostly in amorphous form. Conclusion: The formulation and properties of Acedofenac solid dispersions were established.Xây dựng công thức bào chế hệ phân tán rắn chứa aceclofenac đê tăng tác dụng chống viêm, giảm đau. Kết quả nghiên cứu cho thấy hệ phân tán rắn chứa chất mang PVP K30 với tỷ lệ 1:7 cải thiện được độ tan và độ hòa tan của aceclofenac lớn nhất. Độ tan tăng gấp 9,89 lần so với nguyên liệu. Trong khi đó, độ hòa tan tăng gấp 4,53 lần tại thời điểm 120 phút. Kết quả phổ X-ray, giản đồ nhiệt DCS và chụp SEM cho thấy aceclofenac tồn tại phần lớn ở dạng vô định hình.

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