Nghiên cứu khả năng ức chế 5 dòng tế bào ung thư ở người của cao dịch chiết rễ chùm ngây trong điều kiện in vitro

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Tác giả: Thanh Trang Huỳnh, Hiền Minh Lương, Đức Bách Nguyễn, Thị Cẩm Miện Phí

Ngôn ngữ: vie

Ký hiệu phân loại: 571.538 *Tissue culture

Thông tin xuất bản: Khoa học & Công nghệ Việt Nam, 2018

Mô tả vật lý: 28-31

Bộ sưu tập: Metadata

ID: 536423

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Chủ đề

Nghiên cứu này được tiến hành với mục đích đánh giá hiệu quả tách thu cao dịch chiết rễ chùm ngây của 7 loại dung dịch môi khác nhau, đồng thời đánh giá hiệu quả ức chế 5 dòng tế bào ung thư ở người (ung thư vú - MCF7, gan - HepG2, phối - SK-LU-1, máu - Jurkat và da - SK-Mel-2) của cao dịch chiết rễ chùm ngây trong điều kiện in vitro. Kết quả cho thấy, hiệu quả tách chiết của 7 loại dung môi là khác nhau, trong đó sử dụng dung môi ethanol 96% cho hiệu quả tách chiết cao nhất (đạt 19,66%). Ngoài ra, cao dịch chiết rễ chùm ngây được tách chiết bằng dung môi ethanol 96%, cũng cho hiệu quả ức chế 5 dòng tế bào ung thư ở người cao hơn hẳn so với cao dịch chiết rót chùm ngây được tách chiết bằng nước cất. Ở nồng độ 500 ug/ml, cao dịch chiết rễ chùm ngây được tách chiết bằng dung môi ethanol 96% có khả năng ức chế và diệt được 96,38% tế bào ung thư máu, 86,39% tế bào ung thư vú, 74,28% tế bào ung da, 73,89% tế bào ung thư phổi và 66,22% tế bào ung thư gan.This study was conducted with the aim of evaluating the high separation efficiency of Moringa root extract of 7 different solvent solutions and evaluating the effectiveness of inhibiting 5 human cancer cell lines (breast cancer). - MCF7, liver - HepG2, coordination - SK-LU-1, blood - Jurkat and skin - SK-Mel-2) of Moringa root extract in vitro. The results showed that the extraction efficiency of 7 types of solvents was different, in which using 96% ethanol solvent gave the highest extraction efficiency (reaching 19.66%). In addition, moringa oleifera root extract is extracted with a 96% ethanol solvent, which also inhibits 5 human cancer cell lines significantly higher than that of moringa oleifera extract extracted by distilled water. At a concentration of 500 ug / ml, Moringa root extract extracted from ethanol is 96% capable of inhibiting and killing 96.38% of blood cancer cells, 86.39% of breast cancer cells, 74.28% of skin cancer cells, 73.89% of lung cancer cells and 66.22% of liver cancer cells.

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