Nự thay đổi nồng độ Vitamin B12, Folate và một số chỉ số hóa sinh máu ở 66 bệnh nhân thiếu máu được điều trị tại bệnh viện Quân y 103. Kết quả nghiên cứu cho thấy đa số bệnh nhân thiếu máu có nồng độ Vitamin B12, folate huyết tương bình thường. Có mối tương quan nghịch giữa nồng độ hemoglobin với nồng độ folate huyết tương.Objectives: To study the alter of concentration of vitamin B12, folate and the number of blood biochemical index in anaemia patients. Subjects and methods: patients were diagnosed as anaemia (according to criterion of WHO), included 66 pahents treated in Hospital No.103, examined and tested to diagnose anaemia reasons, defined blood vitamin B12 concentration, blood folate
function of liver and a number of blood biochemical index
defined correlation between vitamin B12, folate with plasma hemoglobin concentration. Results: anaemia patients group suffered from leukemia has highest rate (21.21%), Mulbple Myeloma (MM) (16.67%), the lack of nutritional factors (12.12%), the loss of chronic blood, iron (12.12%), Malignant Lymphomas and hemolytic anaemia (4.55%). The percentage of patients with normal plasma vitamin B12 concetration had highest rate (84.85%), while the percentage of patients with blood normal folate had rate 87.88%, patients has decreased blood vitamin B12 concentration (9,09%), folate (6.06%). Plasma hemoglobin concentration has agreeable correlation with plasma vitamin B12 concentration (y = 0.0025X + 82.233), opposite correlation with plasma folate concentration (r = -0.31), (y = -1.4287x + 96.591). Plasma GGT concentration in anaemia patients has increased lightly (85.39 ± 53.41 U/L)
AST, ALT, bilirubin have normal value. Hemoglobin has opposite. correlation with plasma protein concentration (y = - 0.1021X + 91.107). Conclusion: The most anemic patients have normal concentration of vitamin B12 and folate in plasma. There is a negative correlation between concentration of hemoglobin and concentration of folate in plasma.