Tìm hiểu một số đột biến nhiễm sắc thể ở những cặp vợ chống có tiền sử sẩy thai, thai chết lưu

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Tác giả: Bảo Ngọc Hoàng, Thị Ngọc Lan Hoàng, Trọng Bằng Mạnh, Văn Phương Ngô, Thị Huyền Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại: 581.2 Specific topics in natural history of plants

Thông tin xuất bản: Y học Việt Nam, 2018

Mô tả vật lý: 157-161

Bộ sưu tập: Metadata

ID: 537719

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Khảo sát một số đột biến nhiễm sắc thể trên 122 cặp vợ chống có tiền sử sẩy thai, thai chết lưu được xét nghiệm nhiễm sắc thể. Kết quả cho thấy có 61 cặp vợ chống với 62 đột biến nhiễm sắc thể, chiếm tỷ lệ 4,99%. Đột biến cấu trúc nhiễm sắc thể chiểm 4,66%, đột biến số lượng nhiễm sắc thể chiếm 0,33%. Tỷ lệ đột biến nhiễm sắc thể ở các cặp vợ chồng có tiền sử sẩy thai, thai chết lưu trên 2 lần cao hơn so với nhóm có tiền sử sảy thai và thai chết lưu dưới 2 lần. Cần làm xét nghiệm nhiễm sắc thể cho các cặp vợ chồng có tiền sử sảy thai trên 2 lần.Miscarriage and stillbirth are two of the many reproduction abnormalities. It is cause about severe consequences of psychological, economic burdens for many couples and for the society. Chromosomal abnonnalities are one of ttie causes of misearnage, stillbirth. Objectives: (1) Identify types of chromosomal mutations in couples with a history of miscarriage, stillbirth. (2) The relationship between chromosome mutations and the number of miscarnages and stillbirths. Subjects: 1222 couples with a history of miscaniage, stillbirth have diramosome tests. Study method: retnaspedive desaiption. Results: There were 61 couples with 62 chromosomal mutations, the rate was 4.99% (42 cases in wife, 20 cases in husband). The rate of structural mutation was 4.66%, numberal mutation was 0.33%. The rate of chromosomal mutaBons in couples with a history of >
2 times - miscarriage, stillbirth group was statistically different compared to the couples with a history of <
2 times - miscarriage, stillbirth group. Conclusion: The rate of chromosomal abnormalities in couples with a history of miscarriage, stillbirth was 4.99%. It is recommended to have a chromosome test for couples with a history of >
2 tmes - miscarriage, stillbirth.

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