A knowledge-based planning model to identify fraction-reduction opportunities in brain stereotactic radiotherapy.

• Tác giả: Shane McCarthy, Damodar Pokhrel, William St Clair
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of applied clinical medical physics , 2025
• Bộ sưu tập: NCBI
• ID: 539385

Tóm tắt

OBJECTIVE: To develop and validate a HyperArc-based RapidPlan (HARP) model for three-fraction brain stereotactic radiotherapy (SRT) plans to then use to replan previously treated five-fraction SRT plans. Demonstrating the possibility of reducing the number of fractions while achieving acceptable organs-at-risk (OAR) doses with improved target biological effective dose (BED) to brain lesions. METHODS: Thirty-nine high-quality clinical three-fraction HyperArc brain SRT plans (24-27 Gy) were used to train the HARP model, with a separate 10 plans used to validate its effectiveness. Fifty-eight five-fraction HyperArc brain SRT plans (30-40 Gy) attempted to be retrospectively replanned for three fractions scheme using the HARP model. All planning was done within the Eclipse treatment planning system for a TrueBeam LINAC with a 6 MV-FFF beam and Millenium 120 MLCs and dosimetric parameters were analyzed per brain SRT protocol. RESULTS: The HyperArc RapidPlan model was successfully trained and tested, with the validation set demonstrating a statistically significant (p = 0.01) increase in GTV D CONCLUSIONS: The HARP model developed in this research was used to successfully identify select five-fraction plans that were able to be reduced to three-fraction SRT treatments while achieving clinically acceptable OAR doses and improved target BED. This tool encourages a fast and standardized way to provide physicians with more options when choosing the necessary fractionation scheme(s) for HyperArc SRT to single- and multiple brain lesions.