Aim: To evaluate the effect of fosamax plus in patients with osteoponasis aged 40 years and older. Objects and methods: Sixty patients, 21 males and 39 females aged 40 years or older, had an average age of 58.8 ± 9.5 years, with osteoporosis in Vinh city. Time: 20 months from 11/2015 to 7/2017, in 25 wards of Vinh city. All patients were given fosamax plus (aldronate 70 mg + vitamin D3 5600 UI) once a week, for 6 months and evaluated after 1 month, 3 months, 6 months and 9 months. Results: After 9 months of treatment, the T- score increased from -3.4 ± 0.7 to - 2.0 ± 0.78. The bone density increased from 57.8% ± 22.5% to 77.4% ± 15.2%. Side effects of fosamax plus are: Rash, allergy: 6.7%
Abdominal pain: 10.0%
Nausea, vomiting: 5.0%
Epigastric buming: 10.0%
Yogurt: 10.0%. Esophageal ulcer: 1.6%
Constipation: 3.3%. Conclusion: Fosamax plus works to increase bone density in patients with osteoporosis aged 40 years and older. Side effects are mainly abdominal pain, nausea, burning epigastric.Đánh giá hiệu quả của Fosamax plus ở 60 bệnh nhân loãng xương trên 40 tuổi tại thành phố Vinh, Nghệ An. Kết quả nghiên cứu cho thấy fosamax plus có tác dụng làm tăng mật độ xương ở bệnh nhân loãng xương trên 40 tuổi. Tác dụng phụ chủ yếu là đau bụng, buồn nôn, nóng rát thượng vị.