Objectives: Axillary hyperhidrosis accounts for 1 to 3 percent in tropical countries, which significantly affects patient's activities. A variety of treatment methods are used to control or reduce the profuse sweating, but the results remain limited. Currently, the treatment of axillary hyperhidrosis is still challenging. In this research, the authors evaluated the results of surgical excision of sweat glands in the axillary to treat axillary hyperhidrosis at Department of Plastic and Aesthetic Surgery Cho Ray Hospital. Methods: A descriptive prospective study of 40 patients with axillary hyperhidrosis admitted to the Department of Plastic and Cosmetic Surgery in Cho Ray Hospital from Jan 2013 to Jan 2015 for surgical excision of sweat glands. Evaluation was based on the degree of clinical improvement and satisfaction of patients. Results: Satisfaction rates at one, three and six months respectively were 80 percent, 85 percent and 90 percent. There was one case of unilateral axillary abscess and 01 case of nonhealing incision. Conclusions: The surgical excision of local sweat glands was easy-to-perform and effective method to treat axillary hyperhidrosis. The recurrence rate was low.