Một số đặc điểm bệnh lý chủ yếu của chó được gây nhiễm thực nghiệm bằng chủng virus CDV-HV=Major pathological characteristics of experimentally infected dogs with Canine Distemper Virus CDV-HV strain

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Tác giả: Huyền Nguyễn Thị, Nam Nguyễn Hữu, Nguyễn Vũ Sơn, Phạm Ngọc Thạch

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học kỹ thuật Thú y, 2018

Mô tả vật lý: tr.27

Bộ sưu tập: Metadata

ID: 541324

Thêm vào giỏ

Bệnh Ca-rê (Canine Distemper) là bệnh truyền nhiễm cấp tính do virus gây ra ở chó. Kết quả gây nhiễm 5con chó vàng, Việt Nam, 2 tháng tuổi bằng phương pháp khí dung qua niêm mạc mũi, hầu họng với chủng virusCa-rê CDV-HV, liều 106TCID50/ ml/ con cho thấy:Triệu chứng lâm sàng chủ yếu của chó được gây nhiễm chủng virus Ca-rê (CDV-HV) là sốt, ho, chảy nướcmũi, khó thở, giảm ăn, nôn mửa, tiêu chảy có máu và xuất hiện các nốt sần đỏ trên vùng da bụng.Chó mắc bệnh có số lượng bạch cầu, số lượng hồng cầu, hàm lượng Hb, tỷ khối huyết cầu đều giảm so vớichó đối chứng.Bệnh tích đại thể của chó được gây nhiễm là viêm phổi xuất huyết, viêm ruột xuất huyết, tích nước ở cácxoang, hạch lympho sưng và não sung huyết.Bệnh tích vi thể chủ yếu là sung huyết, xuất huyết và thâm nhiễm tế bào viêm ở các cơ quan: phổi, ruột, hạchlympho, thận, gan. Tế bào nhu mô của gan, thận, hạch lympho, tế bào biểu mô ruột thoái hóa, hoại tử. Bệnh tíchvi thể ở não là sung huyết mạch quản và thâm nhiễm tế bào viêm xung quanh mạch quản não, xuất hiện thể vùitrong nhân tế bào thần kinh (neuron).Tế bào biểu mô phế quản, ruột, tế bào hạch lympho là nơi tập trung nhiều virus Ca-rê được phát hiện bằngphương pháp hóa mô miễn dịchCanine Distemper is an acute viral infectious disease in dogs. This study was conducted to characterizethe pathological features of the infected dog by experimental infection. Five Viet Namese, yellow dogsat 2-months-old were infected with the CDV-HV strain via nasal and oropharyngeal mucosa with adose of 106 TCID50/ml/dog. The studied result showed that the main clinical symptoms of the infecteddogs were fever, cough, nasal discharge, dyspnea, decreased appetite, vomiting, bloody diarrhea andnodules on the skin. All the values of white and red blood cell counts, Hb content as well as blood celldensity were decreased in comparison to those of the control dogs. The gross lesions of the infecteddogs exhibited hemorrhagic pneumonia, hemorrhagic enteritis, fluid storage in the cavities, swollenlymph nodes and brain congestion. Major histological lesions included congestion, haemorrhage andexistence of inflammatory cells in the organs (lung, intestine, lymph node, kidney, liver). The liver,kidneys, lymph nodes, intestinal epithelial cells showed the degeneration and necrosis. The brain tissueswere congested and infiltration of inflammatory cells surrounding the cerebral vascular system, viralinclusions occured in the nerve cells. The bronchial epithelial cells, intestines, lymph nodes exhibitedthe aggression of virus particles.

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