Objectives: to examine the effects of CVVH on water-electrolyte and acid-base balance disorders in septic shock patients. - Subjects: 52 septic shock patients were enrolled to study at ICU - Bachmai hospital (4/2009 - 11/2013) and were treated by SSC 2008 and CVVH. Study methods: intervention and comparison. Results: Weight of the oliguria group was well controlled during CVVH process as well as the nonoliguria group (normal), there were 5 groups of patients with hyponatremia, hypernatremia, hypokalemia, hyperkalemia and acidemia with 13.5 percent, 36.5 percent, 38.5 percent, 17.3 percent and 34.6 percentconsecutively) before CVVH processing but later all were corrected by CVVH. Conclusion: CVVH is an effective method to control water-electrolyte and acid-base balance disorders in septic shock patients.