Nitrofurantoin Versus Comparators in the Treatment of Cystitis due to Extended-Spectrum β-Lactamase-Producing Enterobacterales: A Multicenter Cohort Study.

• Tác giả: Khalid Al Sulaiman, Lulwa Alfaraj, Ohoud Aljuhani, Layan O Almadfaa, Fadwa S Alofi, Shuroug A Alowais, Abdulaziz J Alshehri, Abdulmajeed A Alzahrani, Khalid Bin Saleh, Khalid Eljaaly, Raneen H Mokhtar, Sarah A Radwan, Abrar K Thabit
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : The Annals of pharmacotherapy , 2025
• Bộ sưu tập: NCBI
• ID: 542429

Tóm tắt

 BACKGROUND: The increasing prevalence of extended-spectrum β-lactamase (ESBL)-producing bacteria has limited treatment options for cystitis. The recommendation of nitrofurantoin for treatment is based solely on in vitro studies. OBJECTIVE: We aimed to evaluate the effectiveness of nitrofurantoin versus comparators in treating cystitis due to ESBL-producing Enterobacterales in the clinical setting. METHODS: This was a multicenter retrospective cohort study of afebrile adults with symptomatic cystitis and a urine culture of ≥10 RESULTS: Of 225 patients, 66 received nitrofurantoin and 159 received a comparator. Carbapenems were the most used comparator (57.2%). Clinical cure rates were not significantly different between the groups in crude (77.3% vs 86.2%
  CONCLUSION AND RELEVANCE: Nitrofurantoin was as effective as comparators in treating cystitis due to ESBL-producing Enterobacterales. The inpatient setting was associated with higher odds of relapse. Further larger research trials are needed to validate these findings.