Skepticism about health/vaccination policies during Covid-19 was considered a key example of "science-related populism" mainly based on far-right case studies. However, criticism also spread among various left-wing and environmentalist milieus, which represents an understudied phenomenon. Relying on different strands of scientific literature, and on a qualitative research design aimed both to take account of the political heterogeneity within this critical area and to deepen its links with environmentalism, we aim to highlight the limits and normative implications of its interpretation as solely populism, and to contribute to the elaboration of a different interpretive model. Qualitative and frame-bridging analysis highlighted the consolidation of worldviews in clear opposition to hegemonic values, where the criticism of science finds a more appropriate explanation in a denunciation of the intrusiveness of capitalism in science production, as well as in a rejection of "reductionism" and a claim to self-determination that extend from ecological to health issues.