PURPOSE: We report a case of bilateral neuroretinitis like picture following ingestion of Direct Acting Antivirals (DAAs) in the form of sofosbuvir and velpatasvir, for treatment of Chronic Hepatitis C infection. METHODS: retrospective observational case report and review of literature. RESULTS: A healthy 49 years old male, known case of Chronic heptatis C
developed bilateral painless diminution of vision following treatment with DAAs-sofosbuvir and velpatasvir-for treatment-naïve hepatitis C. After thorough work up, ruling out other causes and stopping of medications there was complete resolution of the lesions. CONCLUSION: Ocular side effects of Direct Acting Antivirals (DAAs) for treatment of Chronic Hepatitis C should be considered, as these are now standard care of treatment for the same.